The researchers stress that no differences between men and women in the use of medications before enrolment in the PsoReg register explained the difference in severe psoriasis cases observed. This new finding of increased prevalence in men has the possibility to motivate sex-specific treatments for the management of severe psoriasis and its comorbidities, such as cardiovascular and metabolic disease.
“For over 70 years, psoriasis researchers have speculated that women have less severe psoriasis compared to men. Our study is the first to investigate sex differences in psoriasis severity using the golden standard of severity measurement, the PASI score. Furthermore, we have also looked more in-depth at distinct elements of the PASI score. The results allow us to verify this thesis in a nationwide population. However, further research is needed to substantiate our findings in different populations,” says Marcus Schmitt-Egenolf.