The U.S. Food and Drug Administration has approved three drugs for fibromyalgia: Lyrica (pregabalin), Cymbalta (duloxetine), and Savella (milnacipran).
These drugs may or may not work for you, or be only partially effective. They can also be expensive or may have side effects, including psychiatric problems, Dr. Baethge says.
Be flexible about your options and be willing to switch if necessary. “Treatment for fibromyalgia is not just one medicine. It’s a lifestyle,” he says.