Adrenal Fatigue: Is It Real?

Other causes of Addison’s disease include:

• Tuberculosis (TB)
• Cancer, such as lymphoma
• AIDS

Addison’s disease can cause fatigue. But it often triggers other symptoms, such as:

• Dark skin on the palms of your hands, knees, elbows, and knuckles
• General weakness
• Dizziness when you stand up
• Lack of menstrual periods

Addison’s disease is rare, McGill says. If you do have fatigue related to your hormones, it’s more likely to be a thyroid problem or diabetes than an adrenal issue, she says.

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