Adrenal Fatigue: Is It Real?

Other causes of Addison’s disease include:

  • Tuberculosis (TB)
  • Cancer, such as lymphoma
  • AIDS

Addison’s disease can cause fatigue. But it often triggers other symptoms, such as:

  • Dark skin on the palms of your hands, knees, elbows, and knuckles
  • General weakness
  • Dizziness when you stand up
  • Lack of menstrual periods

Addison’s disease is rare, McGill says. If you do have fatigue related to your hormones, it’s more likely to be a thyroid problem or diabetes than an adrenal issue, she says.

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