Evidence for eczema is also mounting. “I can say that, based on the experience of my patients with moderate to severe atopic dermatitis treated with oral tofacitinib, pruritus responds over hours or days,” said Dr King.
A randomized, double-blind, vehicle-controlled study of 69 patients with mild to moderate atopic dermatitis showed that tofacitinib ointment was significantly more effective than the vehicle (82% vs 30%). Improvements in itch were seen by day 2, the study investigators report, and sleep disturbance and itch scores dropped significantly over 4 weeks.
Other clinical trials are currently underway, said Dr King.