Classified as a form of localized scleroderma, morphea usually involves isolated patches of hardened skin of varying sizes, shapes, and color that can disappear and come back at any time. There is no internal organ involvement.
This kind of localized scleroderma is usually characterized by a line of thickened skin that may affect the bones and muscles underneath it. It appears most commonly on the arms, legs, or forehead, although it is possible for linear scleroderma to occur in other areas. Usually appearing in childhood, linear scleroderma may affect the growth of limbs.
Systemic scleroderma (systemic sclerosis)
Systemic sclerosis (SSc) is a multi-system autoimmune disease that results in fibrosis (development of scar tissue), vascular damage, and abnormal connective tissue growth in many parts of the body including muscles and joints. These abnormalities lead to the breakdown of the skin, subcutaneous tissue, muscles, and internal organs such as the heart, lungs, kidneys, and intestinal tract.