Protein Triggers Immune Response in Lupus Patients

Reactive oxygen species in cells’ mitochondria trigger an immune response widely detected in patients with lupus, researchers have discovered.

The finding suggests the potential for a new therapeutic avenue to ameliorate the effects of the chronic autoimmune disease.

The study, “Reactive oxygen species induce virus-independent MAVS oligomerization in systemic lupus erythematosus,” was published in the journal Science Signaling.

Patients with systemic lupus erythematosus (SLE) exhibit excessive production of type I interferon (IFN), a response triggered during viral infections. The mechanism that triggers the type I IFN response in lupus has remained unknown, however.

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