Reactive oxygen species in cells’ mitochondria trigger an immune response widely detected in patients with lupus, researchers have discovered.
The finding suggests the potential for a new therapeutic avenue to ameliorate the effects of the chronic autoimmune disease.
The study, “Reactive oxygen species induce virus-independent MAVS oligomerization in systemic lupus erythematosus,” was published in the journal Science Signaling.
Patients with systemic lupus erythematosus (SLE) exhibit excessive production of type I interferon (IFN), a response triggered during viral infections. The mechanism that triggers the type I IFN response in lupus has remained unknown, however.