Anti-Muscarinic Drugs May Reverse Peripheral Neuropathy

 

For years, the conventional wisdom was to treat patients with diabetic peripheral neuropathy but there was no possibility of a cure. New research findings suggest that nerve degeneration may be treatable and that the drugs used to improve this painful condition are already on the market, albeit for other conditions.

Antimuscarinic drugs are known for their use in motion sickness, overactive bladder issues, and a variety of other conditions. While many drugs in this class are nonselective antagonists of muscarinic receptors, some agents can selectively target the muscarinic acetylcholine (Ach) type 1 receptor (M1R), like trihexyphenidyl, which often has been prescribed to Parkinson’s patients.

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