Peripheral neuropathy occurs in various conditions such as:
- Chronic inflammatory demyelinating polyneuropathies which develop subacutely, over weeks or months
- Hereditary motor and sensory neuropathy
- IgM demyelinating paraprotein-related neuropathy, again subacute in onset
- Charcot-Marie-Tooth disease
- Metabolic diseases such as diabetes, porphyria, or uremia
In most cases the high serum immunoglobulins are due to monoclonal gammopathy of unknown etiology. Other conditions which should be diagnosed include amyloidosis, plasmacytoma, or malignancies of the lymphoreticular system.